It is possible to establish relationships between dissolution and disintegration, by for example correlating disintegration times in the dissolution vessel with the dissolution rate at selected sampling times. International Council for Harmonisation (ICH) guideline Q6A states that disintegration testing can substitute for specific dissolution testing in cases where immediate release solid oral drug products, made from highly water soluble drug substances, have been demonstrated to have consistently rapid drug release characteristics. Some disintegration tests are done with simulated gastric or intestinal fluid to see how the dosages will perform when ingested. Disintegration time is the time needed for the drug to break into fragments under certain conditions. Disintegration of tablets is a process in which the API is broken down into tiny fragments or granules to improve its solubility. For any dosage to be absorbed by the body, it has to be in a solution. In the pharmaceutical industry, there is a disintegration test undertaken on drugs to make them ready for absorption into the blood stream. At times the process of disintegration can integrate with dissolution where a solid substance disintegrates into small pieces while dissolving in a solvent until it forms a uniform solution of the solute and the solvent. To disintegrate a substance involves breaking it into small chunks, particles and molecules to improve their solubility. The efficiency of the process is enhanced by DISI electromagnetic Basket Technology that allows easier use and labour saving. The disintegration test agitates tablets in a beaker, continuously monitoring decrease in tablet thickness with every upward stroke of the disintegration apparatus that, with all operations controlled and data analysis safely and easily managed via computer and PH21 software. guidelines and the requirements of FDA 21 CFR Part 11. The ZT 730 series is controlled through an intuitive 7" touch-screen and is capable of storing and retrieving up to 200 products/methods with results and parameters.Charles Ischi Testing Technology offers a range of high precision tablet and capsule disintegration testers that allow exact determination of disintegration time for tablets, in line with USP and EU Ph. Its temperature sensor PT 100 allows constant control of the waterbath temperature. The reliable waterbath technology utilizes the thermal inertia of water to create a steady temperature for testing according to USP/EP standards. AirBasket is available as type A basket with 6 test tubes for standard tablets, or type B basket with 3 test tubes for bigger tablets (according to USP/EP standards). It‘s sensors are also highly durable and enable the AirBasket to be used in acidic media. Its electronics compartment is sealed, making it dishwasher proof. Its newly designed, cable-free AirBasket makes disintegration testing with automatic determination of the disintegration time as easy and fast as possible. The ZT 730 is available with one (ZT 731) or two (ZT 732) individually driven test stations and is equipped with an integrated flow-through heater. The ERWEKA ZT 730 Series with cable-free AirBasket automatically determines the disintegration time of samples by using a unique system of magnets and sensors.
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